ABSTRACT
Objective: To compare the healing effects of dried and acellular human amniotic membrane and Mepitel for coverage of split-thickness graft donor site [STGDS]
Methods: Twenty patients who underwent STGDS regeneration surgery in identical anatomic regions were enrolled in this randomized controlled clinical trial conducted in Hazrate Fatemeh hospital [Iran]. Patients were randomly assigned in 3 groups of wound dressing; group A by Mepitel, group B AmiCare [Dried amniotic membrane] and group C OcuReg-A [Acellular amniotic membrane]. Re-epithelization rate [healing time], pain sensation, scar formation and infection rate were assessed till complete healing was achieved
Results: Our results showed no significant difference between Amicare, OcuReg-A and Mepitel in the features analyzed by us including: Re-epithelization rate [healing time] p=0.573, Pain sensation p=day 4[th]: 0.131, day 8[th]: 0.93 and day 12[th]: 0.365, Scar formation p>0.05 and Infection rate
Conclusion: Our findings confirmed the safety and efficacy of Ami Care [dried amniotic membrane] and OcuReg-A [Acellular amniotic membrane] in treatment of split-thickness donor site in comparison with Mepitel as a standard wound dressing. Trial registration number: IRCT201511118177N12
ABSTRACT
Elevated total plasma Homocysteine, is an independent risk factor for cardiovascular disease. Folate and vitamin B12 have not only a protective effect on cardiovascular disease but also an essential effect on total Homocysteine concentrations [tHcy]. This survey has been conducted to evaluate the determinants of tHcy in 1191 healthy Iranian adults. This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region has been designed and conducted based on MONICA/WHO project. A total of 1191 people have been recruited and assessed on serum Homocysteine, Folic acid and vitamin B12, triglycerides, cholesterol, HDL-C, LDL-C, FBS, BMI, BP and smoking, with interview, questionnaires, examination and blood sampling. Blood samples were analyzed according to standard methods. The variables were assessed in 1191 participants include 416 men [34.9%] and 775 women [65.1%]. Prevalence of hyperhomocysteinemia was correlated significantly with male sex and aging. Hcy levels were inversely related to serum Folate and vitamin B12 concentrations. After further adjustments, we detected a positive correlation between tHcy and age, male sex, smoking and BMI, and a negative one with LDL-C and diabetes. Although there was a correlation between tHcy and blood pressure, after age, sex, BMI and smoking adjustment, it just remained significant in women and with systolic blood pressure. We found that dietary and lifestyle parameters such as Folate intake and smoking habit are the main determinants of distribution of plasma Homocysteine in an apparently healthy population. We assumed that lifestyle changes could have considerable subsequences in public health. Our findings confirm the potential advantages of dietary improvements and increased intake of nutrients along with smoking cessation in order to prevent cardiovascular diseases in high-risk patients
Subject(s)
Humans , Male , Female , Risk Factors , Cardiovascular Diseases/epidemiology , Prevalence , Sex Factors , Age FactorsABSTRACT
Cardiovascular diseases are described as the most important health problems in developing countries which are developed in parallel with industrialization of communities. Based on the high morbidity and mortality of cardiovascular disease, this study was performed for examining the population lab inhabitants' knowledge and practice. In this cross - sectional study, 1576 inhabitants of the Population Lab Region were studied by cluster random sampling in 2002. 181 persons were selected from this population. The frequency of each cardio- vascular diseases risk factor such as; hyperlipidemia, smoking, obesity, hypertension, Diabetes, family history of heart attack, being man, stress and excitement, sedentary life style, salty food, vegetables fruits, fatty food and red meat consumption, were assessed. In addition, the population study's practice regarding controlling the risk factors of cardiovascular diseases was determined, as well. Moreover, specific questionnaire and direct interview were used for collecting data and then the gathering data was analyzed by SPSS and EPI - Info soft wares. In this study, 71.8% of people were women while 28.2% of them were men. Besides, there was a significant relationship between the people's knowledge about cardiovascular disease and the level of their education [P < 0.001]. According to the results, 65.2% of population believed that heart attack was the most prevalent cause of death in comparison with 44% of them considered car accident and 13.3% agreed with cancers. On the other hand, 74% of people used liquid oil in their food and 77.9% of them knew the side effects of unhealthy foods such as; salty food as one of the cardiovascular risk factors. The inhabitants' knowledge regarding to the risk factors of cardiovascular diseases was approximately acceptable. However, there was a significant different between their knowledge and practice. Therefore, providing suitable educational programs for improving people's nutrition, physical activity and the other relevant factors for preventing cardiovascular risk factors would be mentioned